phenobarbital will increase toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers could boost the metabolism of ifosfamide to its Energetic alkylating metabolites.Utilization in Pregnancy. Barbiturates could cause fetal damage when administered to a Expecting girl. Retrospecti